辅助生殖患者孕期唐氏筛查血清学结果分析

　　[摘要] 目的 通過对唐氏筛查血清学结果进行回顾性分析，探讨辅助生殖技术（Assisted Reproductive Technology，ART）助孕是否增加唐氏综合征的风险。 方法 使用1235 AutoDELFIA全自动时间分辨荧光免疫分析系统对2014年12月～2016年5月期间在我院进行产前筛查的52 661例孕妇样本进行孕中期血清学指标检测，并随访其妊娠结局。按妊娠方式分为ART妊娠组和自然妊娠组，检测指标为hAFP MOM值、β-hCG MOM值、PAPPA MOM值等。 结果 早期筛查结果显示，ART妊娠组和自然妊娠组孕妇血清β-hCG MOM，PAPPA MOM，唐氏综合征高风险、中风险和低风险比例比较，差异无统计学意义（P>0.05）。中期筛查结果显示，ART妊娠组AFP MOM显著高于自然妊娠组（P<0.001），但唐氏综合征高风险、中风险和低风险比例比较，差异无统计学意义（P>0.05）。 结论 产前筛查在预防及减少唐氏综合征发病率上具有重要的临床价值，ART技术并不增加唐氏综合征风险。
　　[关键词] 唐氏综合征；辅助生殖技术；产前诊断；出生缺陷
　　[中图分类号] R714.5 [文献标识码] B [文章编号] 1673-9701（2018）08-0063-04
　　Analysis on serological results of down"s screening in patients receiving assisted reproduction during pregnancy
　　CHENG Zhaojun ZHOU Wenjing FENG Ying LIAN Jiejing WANG Chong
　　Center for Reproductive Medicine， Hangzhou Hospital of Gynecology and Obstetrics ，Hangzhou Women and Children"s Hospital， Hangzhou 310008， China
　　[Abstract] Objective To carry out the retrospective analysis on the serological results of Down"s screening， and to investigate whether assisted reproductive technology（ART） for pregnancy assistance increases the risk of Down"s syndrome. Methods A total of 52661 pregnant women samples receiving prenatal screening in our hospital from December 2014 to May 2016 using the 1235 AutoDELFIA automatic time-resolved fluorescence immunoassay system were given the tests of serological indices during the second trimester， and their pregnancy outcome was followed up. According to the pregnancy method， the patients were divided into ART pregnancy group and natural pregnancy group. The test indices were hAFP MOM value， β-hCG MOM value， PAPPA MOM value， etc. Results The results of early screening showed that the serum levels of β-hCG MOM， PAPPA MOM of pregnant women and the percentages of high risk， middle risk and low risk of Down"s syndrome between the ART pregnancy group and natural pregnancy group were not significantly different（P>0.05）. The results of interim screening showed that AFP MOM in ART pregnancy group was significantly higher than that in natural pregnancy group（P<0.001）. However， there was no significant difference in the percentages of high risk， middle risk and low risk of Down"s syndrome（P>0.05）. Conclusion Prenatal screening in the prevention and reduction of the incidence rate of Down"s syndrome has an important clinical value， and ART does not increase the risk of Down"s syndrome.
　　[Key words] Down"s syndrome； Assisted reproductive technology （ART）； Prenatal diagnosis； Birth defect

相关热词搜索：血清学 孕期 生殖 患者 辅助