非索非那定联合皮敏消治疗慢性荨麻疹疗效观察

　　【摘要】 目的：探究慢性蕁麻疹患者接受非索非那定与皮敏消联合治疗的价值。方法：选取2014年1月-2017年10月本院收治的慢性荨麻疹患者280例。根据患者治疗方式不同将其分为对照组（盐酸非索非那定片）和试验组（盐酸非索非那定片+皮敏消胶囊），各140例。比较两组疗效、不良反应、治疗后的生活质量及治疗前后的免疫功能指标和炎症因子水平。结果：试验组治疗总有效率为97.14%，明显高于对照组的87.86%（ 字2=8.700，P=0.003）；两组不良反应发生率比较，差异无统计学意义（P>0.05）；治疗后，两组IgA、IgG、IgM均较治疗前改善，且试验组IgA、IgG的改善程度均优于对照组，比较差异均有统计学意义（P<0.05）；治疗后，两组PCT、CRP水平均低于治疗前，且试验组均低于对照组，比较差异均有统计学意义（P<0.05）；治疗后，试验组运动、睡眠质量合格率为86.43%、84.29%均高于对照组的67.86%、65.71%，比较差异均有统计学意义（P<0.05）。结论：非索非那定联合皮敏消治疗慢性荨麻疹，可促进患者免疫功能的提高，对其炎症因子的分泌进行控制，更好缓解患者的荨麻疹症状，改善其生活质量，且用药安全性较高，意义重大。
　　【关键词】 非索非那定； 皮敏消； 慢性荨麻疹
　　Efficacy of Fexofenadine Combined with Piminxiao in Treatment of Chronic Urticaria/FENG Jiaona，WEI Fangquan，HE Cuiying.//Medical Innovation of China，2018，15（07）：095-099
　　【Abstract】 Objective：To explore the value of Fexofenadine combined with Piminxiao in treatment of chronic urticaria.Method：A total of 280 patients with chronic urticaria treated in our hospital from January 2014 to October 2017 were selected.According to the different treatment methods，they were divided into control group（Fexofenadine Hydrochloride Tablets） and experimental group（Fexofenadine Hydrochloride Tablets+Piminxiao Capsule），140 cases in each group.The effects，adverse reactions，quality of life after treatment，the levels of immune function and inflammatory factors before and after treatment between two groups were compared.Result：The total effective rate of treatment group was 97.14%，which was significantly higher than 87.86% of control group（ 字2=8.700，P=0.003）.The incidence of adverse reactions in two groups was compared，the difference was not statistically significant（P>0.05）.After treatment，the IgA，IgG and IgM in two groups were all improved compared with those of before treatment，and the improvement degree of IgA and IgG in experimental group were better than those of control group，the differences were statistically significant（P<0.05）.After treatment，the levels of PCT and CRP in two groups were lower than those of before treatment，and all of experimental groups were lower than those of control group，the differences were statistically significant（P<0.05）.After treatment，the qualified rate of exercise and sleep quality in experimental group was 86.43% and 84.29%，which were higher than 67.86% and 65.71% in control group，the differences were statistically significant（P<0.05）.Conclusion：Fexofenadine combined with Piminxiao in treatment of chronic urticaria can promote the improvement of immune function，control the secretion of inflammatory cytokines，relieve urticaria symptoms and improve their quality of life，and the medication safety is higher，has a great significance.

相关热词搜索：荨麻疹 疗效 观察 治疗慢性 联合