使用奥美拉唑钠与西咪替丁治疗应激性胃溃疡的效果对比

发布时间:2018-06-23 来源: 日记大全 点击:


  【摘要】 目的:探讨使用奥美拉唑钠与西咪替丁治疗应激性胃溃疡的效果。方法:选取2016年4月-2017年4月笔者所在医院收治的92例应激性胃溃疡患者,采用随机方式分为两组,各46例。两组患者均采用常规治疗,对照组加用西咪替丁进行治疗,观察组加用奥美拉唑钠进行治疗,比较两组患者止血时间与治疗效果。结果:观察组平均止血时间为(21.87±2.62)h,明显短于对照组的(31.24±2.17)h,差异有统计学意义(P<0.05);观察组治疗总有效率较对照组高(97.83% vs 69.57%),差异有统计学意义(P<0.05);观察组血清中促胃液素及胃液pH值指標明显优于对照组,差异有统计学意义(P<0.05)。结论:与西咪替丁比较,临床采用奥美拉挫钠对应激性胃溃疡进行治疗,具有止血快,抑酸效果强,复发率低等优点,治疗效果显著,值得临床进一步推广使用。
  【关键词】 奥美拉唑钠; 西咪替丁; 应激性胃溃疡
  doi:10.14033/j.cnki.cfmr.2018.5.010 文献标识码 B 文章编号 1674-6805(2018)05-0020-02
  【Abstract】 Objective:To compare the curative effect of using Omeprazole Sodium and Cimetidine for the treatment of irritable gastric ulcer.Method:From April 2016 to April 2017,92 patients with irritable stomach ulcer treated in our hospital were randomly divided into two groups and 46 cases in each group.Both groups were treated with conventional treatment,and the control group was treated with Cimetidine,and the observation group was treated with Omeprazole Sodium,and the blood time and treatment effect were compared between the two groups.Result:The mean hemostasis of the observation group was (21.87±2.62)h,significantly shorter than the control group (31.24±2.17)h,and the difference was statistically significant(P<0.05).The total efficiency of observation group was higher than that in the control group(97.83% vs 69.57%),and the difference was statistically significant(P<0.05).The serum gastrin and pH of gastric juice in the observation group were significantly better than the control group,and the differences were statistically significant(P<0.05).Conclusion:Clinical using Omeprazole Sodium in the treatment of irritability gastric compares with Cimetidine,which has quick hemostatic,strong acid suppression effect,low recurrence rate,treatment curative effect is distinct,worthy of further clinical use.
  【Key words】 Omeprazole sodium; Cimetidine; Irritable stomach ulcer
  First-author’s address:Qujing First People’s Hospital,Qujing 655000,China
  应激性胃溃疡通常由药物、创伤,以及烧伤或者受到外界刺激致使的胃黏膜急性损伤,是临床消化内科常见急性病[1-2]。应激性胃溃疡起病急、发病快,往往病情较重,易导致患者黑便、呕血等症状,给患者身体健康带来严重威胁,因此及时采用正确的治疗方法尤为重要[3-4]。本研究分别采用奥美拉唑钠与西咪替丁对其进行治疗,旨在找到临床更为有效的治疗方法,报告如下。
  1 资料与方法
  1.1 一般资料
  选取2016年4月-2017年4月笔者所在医院收治的92例应激性胃溃疡患者,随机分为对照组与观察组,对照组46例,观察组46例。对照组男24例,女22例;年龄最小21岁,最大63岁,平均(41.32±9.45)岁。观察组男22例,女24例;年龄最小19岁,最大61岁,平均(42.56±8.97)岁。两组患者性别、年龄等一般资料比较,差异无统计学意义(P>0.05),有可比性。
  1.2 方法
  两组患者均给予药物对症等常规治疗,对照组加用西咪替丁进行治疗,将西咪替丁(山西普德药业股份有限公司,国药准字H20051568)40 mg溶于浓度为5%的250 ml葡萄糖溶液中静脉滴注,2次/d。观察组加用奥美拉挫钠进行治疗,奥美拉唑钠(阿斯利康制药有限公司生产,国药H20030945)40 mg溶于浓度为0.9%的100 ml氯化钠注射液中静脉滴注,2次/d。两组患者治疗1周后,对其治疗效果及相关临床症状进行比较。

相关热词搜索:应激 胃溃疡 奥美 效果 治疗

版权所有 蒲公英文摘 www.zhaoqt.net