甲巯咪唑与糖皮质激素联合治疗甲状腺功能亢进症合并症的效果分析

　　摘   要：目的  分析甲巯咪唑与糖皮质激素联合治疗甲状腺功能亢进症合并症的临床效果。方法  收集我院2016年3月～2017年3月收治的130例甲状腺功能亢进症合并症患者作为研究对象，随机分为A组和B组，每组65例，A组采用甲巯咪唑治疗，B组采用甲巯咪唑与糖皮质激素联合治疗。对比两组患者临床疗效以及肝功能情况。结果  B组患者治疗总有效率53.85%高于A组患者的35.38%， 差异有统计学意义（P<0.05）。治疗后两组患者丙氨酸氮基转氨酶和天门冬氨酸基转氨低于治疗前，差异有统计学意义（P<0.05）。B组患者治疗后丙氨酸氮基转氨酶和天门冬氨酸基转氨低于A组，差异有统计学意义（P<0.05）。结论  甲巯咪唑与糖皮质激素联合治疗甲状腺功能亢进症合并症效果良好，能促进患者肝功能改善，加速患者恢复，因此可进行临床推广应用。
　　关键词：甲状腺功能亢进症合并症;甲巯咪唑;糖皮质激素
　　中图分类号：R581.1                                  文献标识码：A                                DOI：10.3969/j.issn.1006-1959.2018.05.048
　　文章编号：1006-1959（2018）05-0136-02
　　Analysis of Effects of Methimazole and Glucocorticoids on Complications of Hyperthyroidism
　　MIAO Yan-ru
　　（Department of Endocrinology，Suizhong County Hospital，Suizhong 125200，Liaoning，China）
　　Abstract：Objective  To analyze the clinical effect of methimazole and glucocorticoids in the treatment of hyperthyroidism complications.Methods  A total of 130 cases of hyperthyroidism comorbidities treated in our hospital from March 2016 to March 2017 were collected and randomly divided into group A and group B，with 65 cases in each group.Group A was treated with methimazole. Group B was treated with methimazole and glucocorticoids.The clinical efficacy and liver function of the two groups were compared. Results  The total effective rate of treatment in group B was 53.85%，which was higher than that in group A 35.38%，the difference was statistically significant（P<0.05）.After treatment，alanine aminotransferase and aspartate aminotransferase were lower than before treatment in the two groups，the difference was statistically significant（P<0.05）.Group B of patients after treatment of alanine aminotransferase and aspartate amino transaminase is lower than the group A，the difference was statistically significant（P<0.05）. Conclusion  Methimazole combined with glucocorticoids in the treatment of hyperthyroidism complications with good effect，can promote liver function improvement，accelerate the recovery of patients，it can be carried out in clinical application.
　　Key words：Hyperthyroidism complication;Methimazole;Glucocorticoid
　　甲狀腺功能亢进症合并症（hyperthyroidism complication）是一种比较常见的内分泌系统疾病，这种疾病能够对患者的消化系统以及造血系统造成比较大的伤害，目前临床治疗主要采用甲巯咪唑和丙巯氧嘧啶，或联合倍他乐克等β受体阻滞剂治疗。有研究表明[1]，单纯应用抗甲状腺药物治愈率只有50%，且会造成患者白细泡降低，肝功能受损等不良反应发生，基于此，现对绥中县医院内分泌科2016年3月～2017年3月收治的130例甲状腺功能亢进症合并症患者，进行甲巯咪唑与糖皮质激素联合治疗对临床效果及肝功能损害，现总结如下。

相关热词搜索：咪唑 合并症 激素 效果 治疗